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KMID : 0853020080110020092
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Journal of Korean Burn Society
2008 Volume.11 No. 2 p.92 ~ p.95
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The Clinical Effectiveness of Easyef®(Epidermal Growth Factor Spray) in Pediatric Burns
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Yim Hae-Jun
Lee Boung-Chul
Seo Cheon-Hoon
Kim Do-Hern
Hur Jun
Chun Wook
Cho Yong-Suk
Kim Jong-Hyun
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Abstract
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Purpose: Faster epithelialization of burn wound of 2nd degree or deeper burn with small in size or strong rejection by parents to perform skin grafts is a key factor to achieve optimal clinical outcome. The purpose of this study is to report clinically effective results achieved by using recombinant human epidermal growth factor (Easyef® Daewoong Pharmaceutical) for treating pediatric burns deeper than 2nd degree.
Methods: The study was conducted on 20 pediatric scalding burn patients admitted to our burn center from March to December of 2007 who received the Easyef® treatment. Foam dressings were used to all 20 patients in the initial stage and Easyef® was applied after 2 to 3 days. 1 or 2 minutes after spraying the wound with Easyef®, the conventional foam dressings were applied. Photos were taken for all Easyef® treated areas every other day. The scars of burned area were evaluated using Vancouver Burn Scar Scale at the outpatient clinic 6 months after discharge of hospstal.
Results: 6 months after the completion of treatments, burn scars of 20 pediatric burn patients were measured using Vancouver Burn Scar Scale and divided into 3 groups based on points scored as follow: mild scar for 2 points or less, moderate scar for 3 to 4 points and severe scar for 5 points or greater. Etiology of burn was scalding burn for all 20 patients. After evaluating 20 patients, 14 showed mild scars, 4 showed moderate scars and 2 showed severe scars. Of the 14 patients with mild scars, 7 scored 0 and the mean length of time of complete epithelialization for this group was 16.4 days. The mean length of time of complete epithelialization for the group with 2 points or less was 26.6 days, for the group with 3 to 4 points was 41.5 days and for the group with 5 points or greater was 41 days for the complete ephithelialization to occur.
Conclusion: Using Easyef® is beneficial for 2nd degree or deeper pediatric burns in small size for reducing the time it takes for complete epithelialization and hospital stay. The optimal results of minimal post scar formation can be obtained from pediatric contact burns in small size such as less than 8% TBSA if complete epithelialization can occur within 26 days as shown in our study by using Easyef® with conventional foam dressing materials. If the burn area is larger and the complete epithelialization may take longer than 4 weeks then the surgical treatments would be the appropriate method to achieve optimal results.
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KEYWORD
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Easyef®, Post burn scar, Pediatric burns
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